Involvement of C/EBPβ in monocytic differentiation of acute myeloid leukemia cells induced by LW-218, a new synthesized flavonoid.

@article{Wang2014InvolvementOC,
  title={Involvement of C/EBPβ in monocytic differentiation of acute myeloid leukemia cells induced by LW-218, a new synthesized flavonoid.},
  author={Qi-zhi Wang and Hui Hui and H S Yang and Hongzhong Li and Ying-chao Gao and Zhuoyu Li and Qulian Guo and Na Lu},
  journal={Neoplasma},
  year={2014},
  volume={61 6},
  pages={647-58}
}
Our previous study investigated the effects of differentiation inducted by flavonoids derived from a Chinese herb. In this study, we found that LW-218, a new synthesized flavonoid, inhibited proliferation and induced differentiation of acute myeloid leukemia cells. The IC50s of LW-218 in HL-60, U937, K562, and NB4 cell lines were all less than 5 μM, suggesting greater capacity than compounds we have reported. LW-218 induced differentiation effects including morphologic changes, NBT reduction… CONTINUE READING

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