Involvement of BMP-4/msx-1 and FGF pathways in neural induction in the Xenopus embryo.

@article{Ishimura2000InvolvementOB,
  title={Involvement of BMP-4/msx-1 and FGF pathways in neural induction in the Xenopus embryo.},
  author={Akihiko Ishimura and Ryu Maeda and Masatoshi Takeda and Masaru Kikkawa and Ira O Daar and Mitsugu Ma{\'e}no},
  journal={Development, growth & differentiation},
  year={2000},
  volume={42 4},
  pages={
          307-16
        }
}
The msx homeodomain protein is a downstream transcription factor of the bone morphogenetic protein (BMP)-4 signal and a key regulator for neural tissue differentiation. Xmsx-1 antagonizes the dorsal expression of noggin and cerberus, as revealed by in situ hybridization and reverse transcription-polymerase chain reaction assays. In animal cap explants, Xmsx-1 and BMP-4 inhibit the neural tissue differentiation induced by noggin or cerberus. A loss-of-function study using the Xmsx-1/VP-16 fusion… CONTINUE READING

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