Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic tumor cells

@article{Trisciuoglio2011InvolvementOB,
  title={Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic tumor cells},
  author={Daniela Trisciuoglio and Chiara Gabellini and Marianna Desideri and Ylenia Ragazzoni and Teresa De Luca and Elio Ziparo and Donatella Del Bufalo},
  journal={Cell Death and Differentiation},
  year={2011},
  volume={18},
  pages={1024-1035}
}
In addition to act as an antiapoptotic protein, B-cell lymphoma (bcl)-2 can also promote tumor angiogenesis. In this context, we have previously demonstrated that under hypoxia bcl-2 promotes hypoxia-inducible factor-1 (HIF-1)-mediated vascular endothelial growth factor (VEGF) expression in melanoma and breast carcinoma. Here, we report on the role of the BH4 domain in bcl-2 functions, by showing that removal of or mutations at the BH4 domain abrogate the ability of bcl-2 to induce VEGF protein… CONTINUE READING
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BH4 domain of bcl-2 protein is required for its proangiogenic function under hypoxic condition.

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