A previous study has shown that the stress responsive neurohormone arginine vasopressin (AVP) is activated in the amygdala during early withdrawal from cocaine. The present studies were undertaken to determine whether (1) AVP mRNA levels in the amygdala or hypothalamus, as well as hypothalamic–pituitary–adrenal (HPA) activity, would be altered during… (More)
Figure 7 Plasma hormonal levels of ACTH (pg/ml) (a) and corticosterone (ng/ml) (b) in heroin naı̈ve rats or heroin self-administered rats after foot shock stress with SSR149415 pretreatment. Data shown in graphs are treatment group mean + SEM. Significant differences are indicated: *po0.05 or **po0.01 vs basal level; ##po0.01 vs vehicle + foot shock group.