A previous study has shown that the stress responsive neurohormone arginine vasopressin (AVP) is activated in the amygdala during early withdrawal from cocaine. The present studies were undertaken to determine whether (1) AVP mRNA levels in the amygdala or hypothalamus, as well as hypothalamic–pituitary–adrenal (HPA) activity, would be altered during… (More)
Figure 1 Effects of chronic (10-day) intermittent escalating-dose heroin administration, early (12-h) and late (10-day) spontaneous heroin withdrawal on AVP mRNA levels (pg/mg RNA) in the amygdala. Data shown in graphs are treatment group mean + SEM. Significant differences are indicated: *po0.05 vs control I.