Involvement of Annexin A2 in p53 induced apoptosis in lung cancer

  title={Involvement of Annexin A2 in p53 induced apoptosis in lung cancer},
  author={Yun Huang and Yan Jin and Cheng-hui Yan and Yonghao Yu and Jing Bai and F. -X. Chen and Yu-zhen Zhao and Song-bin Fu},
  journal={Molecular and Cellular Biochemistry},
Tumor suppressor p53 plays important roles in cell cycle regulation, apoptosis and DNA repair in different cell types including lung cancer. There are different p53 apoptotic pathways in high and low metastatic ability lung cancer cells. However, the exactly mechanism in the pathway is still unclear. Here we found that Annexin A2, a Ca2+-dependent phospholipid-binding protein, is involved in p53-mediated apoptosis. First, by using mRNA differential display technique, down-regulated Annexin A2… CONTINUE READING


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