Involvement of AP-1 in interleukin-1alpha-stimulated MMP-3 expression in human trabecular meshwork cells.

@article{Fleenor2003InvolvementOA,
  title={Involvement of AP-1 in interleukin-1alpha-stimulated MMP-3 expression in human trabecular meshwork cells.},
  author={Debra L. Fleenor and I W Pang and Abbot F. Clark},
  journal={Investigative ophthalmology & visual science},
  year={2003},
  volume={44 8},
  pages={3494-501}
}
PURPOSE Stromelysin-1 (MMP-3) degrades extracellular matrix and increases aqueous outflow. In the trabecular meshwork (TM), interleukin (IL)-1alpha is a potent inducer of MMP-3 expression. In different cells, IL-1alpha activates different signaling pathways, such as nuclear factor (NF)-kappaB-mediated protein expression, the phospholipase A(2) (PLA(2… CONTINUE READING