Corpus ID: 26156132

Involvement of 5-hydroxytryptamine1A receptors in the modulation of micturition reflexes in the anesthetized rat.

@article{Lecci1992InvolvementO5,
  title={Involvement of 5-hydroxytryptamine1A receptors in the modulation of micturition reflexes in the anesthetized rat.},
  author={Alessandro Lecci and Sandro Giuliani and Paolo Santicioli and Carlo A. Maggi},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1992},
  volume={262 1},
  pages={
          181-9
        }
}
  • A. Lecci, S. Giuliani, +1 author C. Maggi
  • Published 1 July 1992
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
Intravenous administration of the selective 5-hydroxytryptamine (5-HT)1A receptor agonist 8-hydroxy-2-(di-N-propylaminotetralin (8-OH-DPAT) and of a low doses of buspirone elicited the supraspinal micturition reflex (SMR) in urethane-anesthetized rats when the urinary bladder was filled with just a subthreshold volume of saline (threshold conditions). The effect of i.v. 8-OH-DPAT was abolished by hexamethonium or spiroxatrine. When SMR was elicited by bladder distension (suprathreshold… Expand
Effects of WAY100635, a selective 5-HT1A-receptor antagonist on the micturition-reflex pathway in the rat.
TLDR
The results suggest that 5-HT1A receptors at the L6-S1 level of the spinal cord have an important role in the tonic control of the descending limb of the micturition-reflex pathway in the rat. Expand
Suppression of the micturition reflex in urethane-anesthetized rats by intracerebroventricular injection of WAY100635, a 5-HT1A receptor antagonist
TLDR
The data coupled with the results of previous studies suggest that spinal and supraspinal 5-HT(1A) receptors are involved in multiple inhibitory mechanisms controlling the spinobulbospinal micturition reflex pathway. Expand
The role of 5-HT1A receptors in control of lower urinary tract function in cats
TLDR
5-HT(1A) receptor stimulation is inhibitory to bladder function in cats, especially under conditions where the bladder is hyperactive due to irritation, the exact opposite of the bladder-excitatory effects of 8-OH-DPAT reported in rats. Expand
Role of 5-HT1A receptors in control of lower urinary tract function in anesthetized rats.
TLDR
Results indicate that activation of 5- HT1A receptors by endogenous 5-HT lowers the threshold for initiating reflex voiding and promotes voiding function by enhancing the duration of EUS relaxation, which should reduce urethral outlet resistance. Expand
Role of peripheral 5-HT1A receptors in detrusor over activity associated with partial bladder outlet obstruction in female rats.
TLDR
Observations suggest the involvement of peripheral 5-HT(1A) receptors in detrusor over activity associated with bladder outlet obstruction in female rats. Expand
Suppression of bladder reflex activity in chronic spinal cord injured cats by activation of serotonin 5-HT1A receptors
TLDR
The results suggest that drugs that activate 5-HT1A receptors might be useful in treating detrusor overactivity after spinal cord injury and not on bladder smooth muscle or the efferent limb of the reflex pathway. Expand
Effects of NAD-299, a new, highly selective 5-HT1A receptor antagonist, on bladder function in rats
TLDR
It is concluded that NAD-299, acting at a supraspinal site, can inhibit micturition in the rat. Expand
Multiple sites of action in the inhibitory effect of nociceptin on the micturition reflex.
TLDR
The effects observed after the intravenous administration of nociceptin indicate that the functional integrity of capsaicin-sensitive bladder afferents is required for exerting its inhibitory activity at the peripheral level. Expand
Influence of serotonergic mechanisms on the urine flow rate in male rats.
TLDR
It is suggested that 8-OH-DPAT improved the voiding efficiency by enhancing the detrusor contractile ability and prolonging EUS burst period, which would compensate for the lower UFR, resulting from urethral smooth muscle contractions and longer EUS silent periods during voiding. Expand
5-Hydroxytryptamine-induced bladder hyperactivity via the 5-HT2A receptor in partial bladder outlet obstruction in rats.
TLDR
The results suggest that the increased contractile responses to 5-HT in BOO rat bladder may be partly caused by 5- HT(2A) receptor upregulation in the detrusor smooth muscles. Expand
...
1
2
3
4
5
...