Involvement of 5-HT2 receptors in the LSD- and L-5-HTP-induced suppression of lordotic behavior in the female rat

@article{Sietnieks2005InvolvementO5,
  title={Involvement of 5-HT2 receptors in the LSD- and L-5-HTP-induced suppression of lordotic behavior in the female rat},
  author={A. Sietnieks},
  journal={Journal of Neural Transmission},
  year={2005},
  volume={61},
  pages={65-80}
}
  • A. Sietnieks
  • Published 2005
  • Chemistry, Medicine
  • Journal of Neural Transmission
Copulatory behavior in the ovariectomized rat, the lordotic response (L. R.), was induced by estrogen followed by progesterone. L. R. is inhibited by lysergic acid diethylamide (LSD) (≥0.05 mg/kg) and by Levo-5-hydroxytryptophan (L-5-HTP) (≥2.5 mg/kg). The effects of the putative 5-HT antagonists lisuride, metergoline, methysergide, mianserin, cinanserin, cyproheptadine, pirenperone and altanserin on the LSD-induced inhibition of L. R. were tested. Lisuride, metergoline, methysergide and… Expand
Mescaline: excitatory effects on acoustic startle are blocked by serotonin2 antagonists
  • M. Davis
  • Chemistry, Medicine
  • Psychopharmacology
  • 2004
TLDR
The hypothesis that the behavioral effects of hallucinogens are mediated by agonist actions at 5-HT2 receptors is supported. Expand
Expression and Function of Serotonin 2A and 2B Receptors in the Mammalian Respiratory Network
TLDR
A significant role of both receptors in respiratory network modulation is suggested, given the nature of the signaling pathways, and whether intracellular calcium may explain effects observed in the respiratory network. Expand
Pharmacology of serotonin and female sexual behavior
  • L. Uphouse
  • Psychology, Medicine
  • Pharmacology Biochemistry and Behavior
  • 2014
TLDR
There is substantial evidence to support a role for 5-HT in the modulation of female consummatory sexual behavior, but studies on the role of 5- HT in other elements of female sexual behavior (e.g. desire, motivation, sexual appetite) are few. Expand
Discovery of vanoxerine dihydrochloride as a CDK2/4/6 triple-inhibitor for the treatment of human hepatocellular carcinoma
TLDR
The present study is the first report identifying a new CDK2/4/6 triple inhibitor vanoxerine dihydrochloride, and demonstrated that this drug represents a novel therapeutic strategy for HCC treatment. Expand

References

SHOWING 1-10 OF 46 REFERENCES
Inhibition of 5-hydroxytryptamine-mediated behaviour by the putative 5-HT2 antagonist pirenperone
TLDR
Pirenperone did decrease methamphetamine-induced locomotor activity in rats, and a dose of haloperidol producing a similar inhibition of this response did not alter the 5-HT-mediated behaviour, it is suggested that the currently used 5- HT-induced behavioural models are5-HT2 receptor-mediated. Expand
Progesterone enhancement of lysergic acid diethylamide and levo-5-hydroxytryptophan stimulation of the copulatory response in the female rat.
TLDR
The effects of various hormone treatments on the stimulatory action of LSD were tested and possible mechanisms underlying the observed influence of progesterone on serotonergic mechanisms involved in the lordosis behavior are discussed. Expand
The head-twitch response to intraperitoneal injection of 5-hydroxytryptophan in the rat: Antagonist effects of purported 5-hydroxytryptamine antagonists and of pirenperone, an LSD antagonist
The putative 5-hydroxytryptamine (5-HT) antagonists 2-bromo-LSD, cinanserin, cyproheptadine, pizotifen, methysergide, metitepine, mianserin and metergoline were found to reduce the frequency of theExpand
Enhancement by progesterone of 5-hydroxytryptophan inhibition of the copulatory response in the female rat.
TLDR
A study of the influence of different hormonal treatments used to induce copulatory behavior in ovariectomized female rats on the effects of an endogenous increase of 5-HT or catecholamines achieved by DL-5-HTP and L-Dopa demonstrated that the inhibitory effect of the 5- HT precursor 5-hydroxytryptophan was also potentiated by increased doses of progesterone. Expand
Involvement of 5-HT2 receptors in the wet-dog shake behaviour induced by 5-hydroxytryptophan in the rat
TLDR
It is proposed that the wet-dog shakes induced by5-HTP are mediated by activation of 5-HT2 receptors, and ketanserin, pirenperone and methysergide are proposed as the antagonists that inhibit this behaviour. Expand
Comparison of the action of lysergic acid diethylamide and apomorphine on the copulatory response in the female rat
TLDR
It is concluded that the predominant action of LSD on the female coupulatory response is not mediated by increased dopamine receptor activity but that the LSD effect might be modulated by decreased dopaminergic activity. Expand
Role of hypothalamic alpha and beta adrenergic receptors in the control of lordotic behavior in the ovariectomized-estrogen primed rat
TLDR
Alternative mechanisms were proposed for the possible roles of α- and β-adrenergic receptors in the hypothalamic control of estrogen-induced and LRH-facilitated lordotic behavior and the effects of adrenergic receptor activity on the stimulatory effects of luteinizing hormone-releasing hormone (LRH) upon lordotic Behavior. Expand
The effects of lysergic acid diethylamide on copulatory behaviour in the female rat
The actions of lysergic acid diethylamide (LSD) on a serotonin- and dopamine-dependent functional test, lordotic behaviour in female rats, and other behaviours were investigated. Increasing doses ofExpand
In vivo evidence of partial agonist activity exerted by purported 5-hydroxytryptamine antagonists.
TLDR
The data suggest that cyproheptadine, methysergide and mianserin may produce partial agonist effects in addition to their antagonist action at central 5-HT receptor sites. Expand
Enhancement by progesterone of lysergic acid diethylamide inhibition of the copulatory response in the female rat.
TLDR
Progesterone but not estrogen was found to significantly enhance the LSD effect in a dose-dependent manner, and this has important implications for the possibility that progesterone induces the L.R. by acting on monoaminergic mechanisms. Expand
...
1
2
3
4
5
...