Involvement of 5-HT2 receptors in the LSD- and L-5-HTP-induced suppression of lordotic behavior in the female rat

  title={Involvement of 5-HT2 receptors in the LSD- and L-5-HTP-induced suppression of lordotic behavior in the female rat},
  author={Anni Sietnieks},
  journal={Journal of Neural Transmission},
  • A. Sietnieks
  • Published 2005
  • Chemistry, Medicine
  • Journal of Neural Transmission
Copulatory behavior in the ovariectomized rat, the lordotic response (L. R.), was induced by estrogen followed by progesterone. L. R. is inhibited by lysergic acid diethylamide (LSD) (≥0.05 mg/kg) and by Levo-5-hydroxytryptophan (L-5-HTP) (≥2.5 mg/kg). The effects of the putative 5-HT antagonists lisuride, metergoline, methysergide, mianserin, cinanserin, cyproheptadine, pirenperone and altanserin on the LSD-induced inhibition of L. R. were tested. Lisuride, metergoline, methysergide and… Expand
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Progesterone enhancement of lysergic acid diethylamide and levo-5-hydroxytryptophan stimulation of the copulatory response in the female rat.
The effects of various hormone treatments on the stimulatory action of LSD were tested and possible mechanisms underlying the observed influence of progesterone on serotonergic mechanisms involved in the lordosis behavior are discussed. Expand
The head-twitch response to intraperitoneal injection of 5-hydroxytryptophan in the rat: Antagonist effects of purported 5-hydroxytryptamine antagonists and of pirenperone, an LSD antagonist
The putative 5-hydroxytryptamine (5-HT) antagonists 2-bromo-LSD, cinanserin, cyproheptadine, pizotifen, methysergide, metitepine, mianserin and metergoline were found to reduce the frequency of theExpand
Enhancement by progesterone of 5-hydroxytryptophan inhibition of the copulatory response in the female rat.
A study of the influence of different hormonal treatments used to induce copulatory behavior in ovariectomized female rats on the effects of an endogenous increase of 5-HT or catecholamines achieved by DL-5-HTP and L-Dopa demonstrated that the inhibitory effect of the 5- HT precursor 5-hydroxytryptophan was also potentiated by increased doses of progesterone. Expand
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Role of hypothalamic alpha and beta adrenergic receptors in the control of lordotic behavior in the ovariectomized-estrogen primed rat
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Enhancement by progesterone of lysergic acid diethylamide inhibition of the copulatory response in the female rat.
Progesterone but not estrogen was found to significantly enhance the LSD effect in a dose-dependent manner, and this has important implications for the possibility that progesterone induces the L.R. by acting on monoaminergic mechanisms. Expand