Involvement of 5-HT1B receptors within the ventral tegmental area in regulation of mesolimbic dopaminergic neuronal activity via GABA mechanisms: a study with dual-probe microdialysis

@article{Yan2004InvolvementO5,
  title={Involvement of 5-HT1B receptors within the ventral tegmental area in regulation of mesolimbic dopaminergic neuronal activity via GABA mechanisms: a study with dual-probe microdialysis},
  author={Qing-shan Yan and Shi-Zhong Zheng and Shu-E Yan},
  journal={Brain Research},
  year={2004},
  volume={1021},
  pages={82-91}
}
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72 Citations
Highly Influential Citations
10
Background Citations
36
Methods Citations
1
Results Citations
4

72 Citations

Ethanol and Mesolimbic Serotonin / Dopamine Interactions via 5-HT-lB Receptors

The results suggest that activation of VTA 5-HTIB receptors increases mesolimbic DA neuron activities, and this increased DA neuron activity may be associated, at least in part, with the 5HTIB receptor-mediated inhibition of Vta GABA release.

Involvement of 5-HT1B receptors within the ventral tegmental area in ethanol-induced increases in mesolimbic dopaminergic transmission

Award Number: DAMD17-02-1-0187 TITLE: Ethanol and Mesolimbic Serotonin/Dopamine Interactions via 5HT-1B Receptors

The results suggest that activation of VTA 5-HT1B receptors increases mesolimbic DA neuron activities, and this increased DA neuron activity may be associated, at least in part, with the 5 HT1B receptor-mediated inhibition of Vta GABA release.

TITLE: Ethanol and Mesolimbic Serotonin/Dopamine Interactions Via 5-HT1B Receptors

The results suggest that blockade and activation of VTA 5-HT1B receptors attenuates and potentiates the neurochemical effects of ethanol, respectively, and support the suggestion that VTA 4-HT2B receptors may be involved in part in mediating the activating effects ofanol on mesolimbic DA neurons.

Peripheral Administration of Ethanol Results in a Correlated Increase in Dopamine and Serotonin Within the Posterior Ventral Tegmental Area.

The current findings suggest that the ability of EtOH to stimulate DA activity within the mesolimbic system may be modulated by increases in 5-HT release within the pVTA.

Effects of systemic 5-HT(1B) receptor compounds on ventral tegmental area intracranial self-stimulation thresholds in rats.

Serotonin control of central dopaminergic function: focus on in vivo microdialysis studies.

Repeated administration of the 5-HT1B/1A agonist, RU 24969, facilitates the acquisition of MDMA self-administration: role of 5-HT1A and 5-HT1B receptor mechanisms

Data suggest that the initial reinforcing effects of MDMA are modulated by 5-HT1A and/or 5- HT1B receptor mechanisms, and a possible role in conditioned reinforcement pertaining to acquisition of self-administration is discussed.

Neural Circuits Associated with 5-HT1B Receptor Agonist Inhibition of Methamphetamine Seeking in the Conditioned Place Preference Model.

The findings suggest that CP94253 attenuates the motivational effects of the Meth-associated environment and highlight the amygdala, VTA, NAc, and dorsomedial striatum as potential regions involved in this effect.

Serotonin1B heteroreceptor activation induces an antidepressant-like effect in mice with an alteration of the serotonergic system.

The results demonstrate that the antidepressant-like effect of SSRIs in the FST requires the activation of 5-HT1B heteroreceptors, which antagonizes the effect of selective serotonin reuptake inhibitors (SSRIs).
...

References

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