Involvement of 5-HT1B receptors within the ventral tegmental area in regulation of mesolimbic dopaminergic neuronal activity via GABA mechanisms: a study with dual-probe microdialysis

@article{Yan2004InvolvementO5,
  title={Involvement of 5-HT1B receptors within the ventral tegmental area in regulation of mesolimbic dopaminergic neuronal activity via GABA mechanisms: a study with dual-probe microdialysis},
  author={Qing-shan Yan and Shi-Zhong Zheng and Shu-E Yan},
  journal={Brain Research},
  year={2004},
  volume={1021},
  pages={82-91}
}

Ethanol and Mesolimbic Serotonin / Dopamine Interactions via 5-HT-lB Receptors

The results suggest that activation of VTA 5-HTIB receptors increases mesolimbic DA neuron activities, and this increased DA neuron activity may be associated, at least in part, with the 5HTIB receptor-mediated inhibition of Vta GABA release.

Award Number: DAMD17-02-1-0187 TITLE: Ethanol and Mesolimbic Serotonin/Dopamine Interactions via 5HT-1B Receptors

The results suggest that activation of VTA 5-HT1B receptors increases mesolimbic DA neuron activities, and this increased DA neuron activity may be associated, at least in part, with the 5 HT1B receptor-mediated inhibition of Vta GABA release.

TITLE: Ethanol and Mesolimbic Serotonin/Dopamine Interactions Via 5-HT1B Receptors

The results suggest that blockade and activation of VTA 5-HT1B receptors attenuates and potentiates the neurochemical effects of ethanol, respectively, and support the suggestion that VTA 4-HT2B receptors may be involved in part in mediating the activating effects ofanol on mesolimbic DA neurons.

Peripheral Administration of Ethanol Results in a Correlated Increase in Dopamine and Serotonin Within the Posterior Ventral Tegmental Area.

The current findings suggest that the ability of EtOH to stimulate DA activity within the mesolimbic system may be modulated by increases in 5-HT release within the pVTA.

Repeated administration of the 5-HT1B/1A agonist, RU 24969, facilitates the acquisition of MDMA self-administration: role of 5-HT1A and 5-HT1B receptor mechanisms

Data suggest that the initial reinforcing effects of MDMA are modulated by 5-HT1A and/or 5- HT1B receptor mechanisms, and a possible role in conditioned reinforcement pertaining to acquisition of self-administration is discussed.

Neural Circuits Associated with 5-HT1B Receptor Agonist Inhibition of Methamphetamine Seeking in the Conditioned Place Preference Model.

The findings suggest that CP94253 attenuates the motivational effects of the Meth-associated environment and highlight the amygdala, VTA, NAc, and dorsomedial striatum as potential regions involved in this effect.

Serotonin1B heteroreceptor activation induces an antidepressant-like effect in mice with an alteration of the serotonergic system.

The results demonstrate that the antidepressant-like effect of SSRIs in the FST requires the activation of 5-HT1B heteroreceptors, which antagonizes the effect of selective serotonin reuptake inhibitors (SSRIs).
...

References

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The results provide evidence for localization of GABAA, GABAB NMDA, non-NMDA, and cholinergic receptors on dopamine neurons in the VTA and suggest that dopamine neurons on the ventral tegmental area of the rat brain are tonically inhibited by GABA and dopamine by acting on GAB AA, and D2 receptors.

GABAA Receptor Blockade in the Anterior Ventral Tegmental Area Increases Extracellular Levels of Dopamine in the Nucleus Accumbens of Rats

The results suggest that DA neurons projecting from the anterior VTA to the ACB are tonically inhibited by GABA through its actions at the GABAA receptors.

Systemic nicotine‐induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area

The results suggest that nicotinic receptors in the somatodendritic region may be of greater importance than those located in the terminal area for the stimulatory action of systemic NIC on the mesolimbic DA system and support the notion that the meslimbic dopaminergic system is phasically rather than tonically regulated by nicotinics receptor activation within the VTA.

Autoregulation and monoamine interactions in the ventral tegmental area in the absence and presence of cocaine: a microdialysis study in freely moving rats.

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The analysis of behavioral/neurochemical relationships revealed a negative correlation between dialysate NE output and motor activity in the cocaine alone and idazoxan/cocaine groups, and a positive correlation between Dialysate DA output andMotor Activity in the sulpiride/c Cocaine and methiothepin/cocaaine groups.
...