Involvement of 5-HT1A receptors in the anxiolytic action of S 14671 in the pigeon conflict test

  title={Involvement of 5-HT1A receptors in the anxiolytic action of S 14671 in the pigeon conflict test},
  author={R. Schreiber and M. Brocco and B. D. Ladonchamps and M. Millan},
  journal={Pharmacology Biochemistry and Behavior},
  • R. Schreiber, M. Brocco, +1 author M. Millan
  • Published 1995
  • Chemistry, Medicine
  • Pharmacology Biochemistry and Behavior
  • In the pigeon conflict test of anxiety, the novel, high efficacy 5-HT1A receptor ligand, S 14671, very potently [minimal effective dose (MED): 0.0025 mg/kg, IM] and markedly (maximal percentage increase relative to control: 17232%) increased punished responding. In analogy, its structural analogue, the 5-HT1A receptor agonist, S 14506, equipotently, though less markedly, augmented punished responding (MED: 0.0025 mg/kg; maximal effect: 5557%). In contrast, the arylpiperazine 5-HT1A receptor… CONTINUE READING
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