Involvement of 5‐HT3 receptors in the development and expression of methamphetamine‐induced behavioral sensitization: 5‐HT3A receptor channel and binding study

  title={Involvement of 5‐HT3 receptors in the development and expression of methamphetamine‐induced behavioral sensitization: 5‐HT3A receptor channel and binding study},
  author={Ji-Hoon Yoo and Jae-Han Cho and Hyun Sook Yu and Kwang-Wook Lee and Byung-Hwan Lee and Sang Min Jeong and Seung-Yeol Nah and Hyoung‐Chun Kim and Seok-Yong Lee and Choon-Gon Jang},
  journal={Journal of Neurochemistry},
Methamphetamine (MAP) is one of the most commonly abused drugs in Asia, and previous studies suggest that serotonin 3 receptors (5‐HT3) are involved in MAP‐induced locomotion and reward. However, little is known about the role of 5‐HT3 receptors in MAP‐induced behavioral sensitization. Here, we measured the effects of MDL 72222, a 5‐HT3 antagonist, and SR 57227 A, a 5‐HT3 agonist, on the development and expression of MAP‐induced behavioral sensitization, and alternations of 5‐HT3 receptor… 

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