Involvement of 15-lipoxygenase in early stages of atherogenesis

@article{Khn1994InvolvementO1,
  title={Involvement of 15-lipoxygenase in early stages of atherogenesis},
  author={Hartmut K{\"u}hn and Jutta Belkner and Siegfried Zaiss and T F{\"a}hrenklemper and Stefan Wohlfeil},
  journal={The Journal of Experimental Medicine},
  year={1994},
  volume={179},
  pages={1903 - 1911}
}
The arachidonate 15-lipoxygenase which is expressed in atherosclerotic lesions is implicated in the oxidative modification of low density lipoproteins during atherogenesis. To obtain experimental in vivo evidence for this hypothesis, we analyzed the structure of oxygenated lipids isolated from the aorta of rabbits fed with a cholesterol-rich diet for different time periods and compared the pattern of oxygenation products with that isolated from low density lipoproteins treated in vitro with the… CONTINUE READING

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