Involvement of α-synuclein in Parkinson's disease and other neurodegenerative disorders

@article{Krger2000InvolvementO,
  title={Involvement of $\alpha$-synuclein in Parkinson's disease and other neurodegenerative disorders},
  author={R. Kr{\"u}ger and T. M{\"u}ller and O. Riess},
  journal={Journal of Neural Transmission},
  year={2000},
  volume={107},
  pages={31-40}
}
Summary. A major step in the elucidation of the pathogenesis of neurodegenerative disorders was the identification of a mutation in the α-synuclein gene in autosomal dominant Parkinson's disease (PD). α-Synuclein is the main component of Lewy bodies (LB), the neuropathological hallmark of PD. Moreover, a fragment of α-synuclein (NAC) is the second major component of amyloid plaques in Alzheimer's disease (AD). Recent studies of other neurodegenerative disorders such as dementia with LB (DLB… Expand
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