Involvement and unusual substrate specificity of a prolyl oligopeptidase in class III lanthipeptide maturation.

@article{Vller2013InvolvementAU,
  title={Involvement and unusual substrate specificity of a prolyl oligopeptidase in class III lanthipeptide maturation.},
  author={Ginka H. V{\"o}ller and Bartlomiej Krawczyk and Paul Ensle and Roderich D. S{\"u}ssmuth},
  journal={Journal of the American Chemical Society},
  year={2013},
  volume={135 20},
  pages={
          7426-9
        }
}
Lanthipeptides represent an important group of ribosomally synthesized and post-translationally modified peptides (RiPPs). Commonly, in the last steps of their maturation, a part of the peptide, termed the leader, is removed, providing the active compound. This contribution describes for the first time the identification of a protease involved in the removal of the leader peptide of a class III lanthipeptide. Four putative class III biosynthetic gene clusters were identified in bacterial… Expand
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