Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model.

@article{Neuenschwander1996InvolutionOT,
  title={Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model.},
  author={S Neuenschwander and Adi Schwartz and Teresa L Wood and Claire T. Roberts and Lothar Hennighausen and Derek Leroith},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={97 10},
  pages={2225-32}
}
Development of the mammary gland during puberty, pregnancy, and lactation is controlled by steroid and peptide hormones and growth factors. To determine the role of the insulin-like growth factors (IGFs) in this process we developed a transgenic model using the whey acidic protein (WAP) gene to direct expression of rat IGF-I and human IGF binding protein-3 (IGFBP-3) to mammary tissue during late pregnancy and throughout lactation. High levels of expression of transgenic IGF-I and IGFBP-3 were… CONTINUE READING

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Insulin-like growth factor-binding protein enhancement of insulin-like growth factor-I (IGF-I)-mediated DNA synthesis and IGF-I binding in a human breast carcinoma cell line

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