Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model.

  title={Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model.},
  author={S Stefan Neuenschwander and Andrew Schwartz and Teresa L. Wood and Charles T. Roberts and Lothar Hennighausen and Derek Leroith},
  journal={The Journal of clinical investigation},
  volume={97 10},
Development of the mammary gland during puberty, pregnancy, and lactation is controlled by steroid and peptide hormones and growth factors. To determine the role of the insulin-like growth factors (IGFs) in this process we developed a transgenic model using the whey acidic protein (WAP) gene to direct expression of rat IGF-I and human IGF binding protein-3 (IGFBP-3) to mammary tissue during late pregnancy and throughout lactation. High levels of expression of transgenic IGF-I and IGFBP-3 were… 

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