Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model.

S Neuenschwander; Adi Schwartz; Teresa L Wood; Claire T. Roberts; Lothar Hennighausen; Derek Leroith

@article{Neuenschwander1996InvolutionOT, title={Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model.}, author={S Neuenschwander and Adi Schwartz and Teresa L Wood and Claire T. Roberts and Lothar Hennighausen and Derek Leroith}, journal={The Journal of clinical investigation}, year={1996}, volume={97 10}, pages={2225-32} }

Development of the mammary gland during puberty, pregnancy, and lactation is controlled by steroid and peptide hormones and growth factors. To determine the role of the insulin-like growth factors (IGFs) in this process we developed a transgenic model using the whey acidic protein (WAP) gene to direct expression of rat IGF-I and human IGF binding protein-3 (IGFBP-3) to mammary tissue during late pregnancy and throughout lactation. High levels of expression of transgenic IGF-I and IGFBP-3 were… CONTINUE READING

Development of the mammary gland and lactation.

James A. Rillema
Trends in endocrinology and metabolism: TEM
1994

Chen, J.-C, +6 authors J. A. Fontana
J. Cell. Physiol
1994

Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model.

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