Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model.

@article{Neuenschwander1996InvolutionOT,
  title={Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model.},
  author={S Stefan Neuenschwander and Arthur Schwartz and Teresa L. Wood and Charles T. Roberts and Lothar Hennighausen and Derek Leroith},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={97 10},
  pages={
          2225-32
        }
}
Development of the mammary gland during puberty, pregnancy, and lactation is controlled by steroid and peptide hormones and growth factors. To determine the role of the insulin-like growth factors (IGFs) in this process we developed a transgenic model using the whey acidic protein (WAP) gene to direct expression of rat IGF-I and human IGF binding protein-3 (IGFBP-3) to mammary tissue during late pregnancy and throughout lactation. High levels of expression of transgenic IGF-I and IGFBP-3 were… Expand
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TLDR
It is demonstrated that IGFBP-5, although not essential for normal growth, is required for normal mammary gland involution and can regulate Mammary gland morphogenesis in response to hormone stimulation. Expand
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It is hypothesize that IGF-I partially mediates actions of GH in mammary gland development and causes ductal hypertrophy in the lactating mouse and prevention of post-lactational mammary glands involution. Expand
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IGBP-5 seems important for regulating both apoptosis and cell proliferation in the mammary gland during development and post-lactation involution and intracellular events involving nuclear localisation of IGFBP- 5 have been shown to have the ability to inhibit cell proliferation. Expand
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The data suggest that loss of Igfpb7 induces precocious involution possibly through diminished cell survival signals, and identifies Igfbp7 as major regulator of involution in the mammary gland. Expand
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It is proposed that the function of this binding protein is to inhibit IGF-mediated cell survival and thereby to induce apoptotic cell death in mammary glands and this is an important aspect of its anti-apoptotic effect. Expand
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TLDR
Important functions for the family of IGFBPs during postnatal growth and differentiation of the mammary epithelium are suggested. Expand
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A relationship between levels of apoptosis and IGFBP-5 mRNA expression in the bovine mammary gland is demonstrated and the involvement of this binding protein programmed cell death and its relationship with the main lactogenic hormones is confirmed. Expand
The IGF System in Mammary Development and Breast Cancer
  • D. Yee, T. Wood
  • Biology, Medicine
  • Journal of Mammary Gland Biology and Neoplasia
  • 2008
TLDR
The IGFs, receptors and binding proteins have emerged as critical mediators in growth of mammary/breast epithelium both in normal developmental processes and in tumorigenesis and their role as endocrine versus autocrine/ paracrine growth factors is reviewed. Expand
IGF-I: An Essential Factor in Terminal End Bud Formation and Ductal Morphogenesis
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The hypothesis that GH acts through locallyproduced IGF-I, which in turn, causes development of terminal end buds (TEBs), the structure that lead the process of mammary gland development during puberty is proven. Expand
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