Involucrin expression is decreased in Hailey-Hailey keratinocytes owing to increased involucrin mRNA degradation.


Hailey-Hailey disease (HHD) (MIM 16960) is an autosomal-dominant blistering skin disease caused by a mutation in the Ca2+-ATPase ATP2C1 (protein SPCA1), responsible for controlling Ca2+ concentrations in the cytoplasm and Golgi in human keratinocytes. Cytosolic Ca2+ concentrations, in turn, play a major role in the regulation of keratinocyte differentiation… (More)



Citations per Year

Citation Velocity: 13

Averaging 13 citations per year over the last 3 years.

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