Involucratustones A-C: Unprecedented Sesquiterpene Dimers Containing Multiple Contiguous Quaternary Carbons from Stahlianthus involucratus.

Abstract

Involucratustones A-C (1-3), three cadinane dimers containing multiple contiguous quaternary carbons, were isolated from the rhizomes of Stahlianthus involucratus. Their structures were determined by a combination of NMR spectroscopy, chemical conversion, and X-ray diffraction analysis. Compounds 1 and 2 are rearranged homodimers of cadinane sesquiterpene fused with a unique fully substituted 1-oxaspiro[4.4]nonane core observed for the first time in natural products, and 3 is a novel 3',4'-seco-cadinane-dimer. Compounds 1 and 2 exhibited potent cytotoxic activities, and 3 showed notable anti-inflammatory effect.

DOI: 10.1002/chem.201502631

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Cite this paper

@article{Li2015InvolucratustonesAU, title={Involucratustones A-C: Unprecedented Sesquiterpene Dimers Containing Multiple Contiguous Quaternary Carbons from Stahlianthus involucratus.}, author={Qiang-Ming Li and Jian-Guang Luo and Yang-mei Zhang and Zhong-rui Li and Xiaobing Wang and Ming-Hua Yang and Jun Luo and Hongbin Sun and Yi-jun Chen and Lingyi Kong}, journal={Chemistry}, year={2015}, volume={21 38}, pages={13206-9} }