Involment of p53, Bax, and Bcl-2 pathway in microcystins-induced apoptosis in rat testis.

@article{Li2011InvolmentOP,
  title={Involment of p53, Bax, and Bcl-2 pathway in microcystins-induced apoptosis in rat testis.},
  author={Guang-Yu Li and Zhanfeng Wang and Hui-ying Li and L Y Hao and Qian Xiong and Tong Qiu},
  journal={Environmental toxicology},
  year={2011},
  volume={26 2},
  pages={111-7}
}
It has been reported that microcystins (MCs) could accumulate in the gonads of mammals and MCs exposure exerts obvious toxic effects on male reproductive system of mammals. We have comfirmedthat MCs could accumulate and induce apoptosis in rat testis. The p53, Bax, and Bcl-2 protein play important roles in mitochondria-dependent apoptotic pathway, and this study aimed to investigate whether the p53, Bax, and Bcl-2 pathway is involved in microcystins-induced apoptosis in rat testis and discussed… CONTINUE READING

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