Invivo inactivation of γ-aminobutyric acid-α-ketoglutarate transaminase by 4-amino-5-fluoropentanoic acid

@article{Silverman1981InvivoIO,
  title={Invivo inactivation of $\gamma$-aminobutyric acid-$\alpha$-ketoglutarate transaminase by 4-amino-5-fluoropentanoic acid},
  author={Richard B. Silverman and Mark Alan Levy and A. Jabbar Muztar and James D. Hirsch},
  journal={Biochemical and Biophysical Research Communications},
  year={1981},
  volume={102},
  pages={520-523}
}
Abstract Intraperitoneal injection into mice of varying concentrations of (S)-4-amino-5-fluoropentanoic acid ((S)-AFPA) produces a dose-dependent irreversible decrease in brain γ-aminobutyric acid-α-ketoglutaric acid aminotransferase (E.C. 2.6.1.19) activity. Concomitant with this inactivation is an increase in whole brain γ-aminobutyric acid (GABA) levels. Four hours after a dose of 100 mg/kg body weight of (S)-AFPA to mice, endogenous brain GABA concentrations increase to 16 times that of the… Expand
10 Citations
Enzyme-activated irreversible inhibition of rat and mouse brain 4-aminobutyric acid-alpha-ketoglutarate transaminase by 5-fluoro-4-oxo-pentanoic acid.
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