Invited review: the evolution of antidepressant mechanisms.

  title={Invited review: the evolution of antidepressant mechanisms.},
  author={David A Slattery and Alan L. Hudson and David J. Nutt},
  journal={Fundamental & clinical pharmacology},
  volume={18 1},
Present antidepressants are all descendents of the serendipitous findings in the 1950s that the monoamine oxidase inhibitor iproniazid and the tricyclic antidepressant imipramine were effective antidepressants. The identification of their mechanism of action, and those of reserpine and amphetamine, in the 1960s, led to the monoamine theories of depression being postulated; first, with noradrenaline then 5-hydroxytryptamine being considered the more important amine. These monoamine theories of… CONTINUE READING


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