Invited review: mechanisms of ventilator-induced lung injury: a perspective.

  title={Invited review: mechanisms of ventilator-induced lung injury: a perspective.},
  author={C C Dos Santos and Arthur S Slutsky},
  journal={Journal of applied physiology},
  volume={89 4},
Despite advances in critical care, the mortality rate in patients with acute lung injury remains high. Furthermore, most patients who die do so from multisystem organ failure. It has been postulated that ventilator-induced lung injury plays a key role in determining the negative clinical outcome of patients exposed to mechanical ventilation. How mechanical ventilation exerts its detrimental effect is as of yet unknown, but it appears that overdistension of lung units or shear forces generated… CONTINUE READING
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