Invited review: Drug development for tauopathies.

@article{Grueninger2015InvitedRD,
  title={Invited review: Drug development for tauopathies.},
  author={Fiona Grueninger},
  journal={Neuropathology and applied neurobiology},
  year={2015},
  volume={41 1},
  pages={
          81-96
        }
}
Many different approaches to treating tauopathies are currently being explored, with a few compounds already in clinical development (including small molecules such as anti-aggregation compound LMTX and active vaccines AADvac1 and ACI-35). This review aims to summarize the status of the clinical candidates and to highlight the emerging areas of research that hold promise for drug development. Tau is post-translationally modified in several different ways (phosphorylated, acetylated… CONTINUE READING
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