Invited Review: pulmonary alveoli: formation, the "call for oxygen," and other regulators.

@article{Massaro2002InvitedRP,
  title={Invited Review: pulmonary alveoli: formation, the "call for oxygen," and other regulators.},
  author={Donald Massaro and Gloria Decarlo Massaro},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2002},
  volume={282 3},
  pages={L345-58}
}
The lung's only known essential function is to provide sufficient alveolar surface to meet the organism's need for oxygen and elimination of CO(2). The importance of the magnitude of alveolar surface area (Sa) to O(2) uptake (VO(2)) is supported by the presence among mammals of a direct linear relationship between Sa and VO(2). This match has been achieved, despite the higher body mass-specific VO(2) of small organisms compared with large, by a greater subdivision of alveolar surface, not by a… CONTINUE READING