Investigations on the C1q-calreticulin-phosphatidylserine interactions yield new insights into apoptotic cell recognition.

@article{Padassi2011InvestigationsOT,
  title={Investigations on the C1q-calreticulin-phosphatidylserine interactions yield new insights into apoptotic cell recognition.},
  author={Helena Pa{\"i}dassi and Pascale Tacnet-Delorme and M{\'e}lanie Verneret and Christine Gaboriaud and Gunnar Houen and Karen Duus and Wai Li Ling and G{\'e}rard J. Arlaud and Philippe Frachet},
  journal={Journal of molecular biology},
  year={2011},
  volume={408 2},
  pages={277-90}
}
Both C1q and calreticulin (CRT) are involved in the recognition of apoptotic cells. CRT was initially characterized as a receptor for the C1q collagen-like fragment (CLF), whereas C1q was shown to bind apoptotic cells through its globular region (GR). Using purified CRT and recombinant CRT domains, we now provide unambiguous experimental evidence that, in addition to its CLF, the C1q GR also binds CRT and that both types of interactions are mediated by the CRT globular domain. Surface plasmon… CONTINUE READING

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