One hundred and fifty-two cases of changes in diagnosis of 'schizophrenia', 'endogenous depression' and 'psychopathia' in the course of illness, are statistically analyzed in regard to tendency of changes of diagnosis, sex, symptomatics and syndromatics, age of onset and duration of cycles. The changes of diagnosis show a clear tendency in favour of the diagnosis of 'schizophrenia' as opposed to 'psychopathia'. Among the cases with changed diagnoses, women are significantly over-represented. On the level of symptomatics, few significant changes of symptom frequencies can be found. More information can be obtained in the analysis on syndromatics: four out of six groups show significant changes in the intensity of syndromes; on the basis of similarities in syndrome profiles, derived from materials which are diagnostically homogeneous, the actual diagnostic components can be evaluated. The analysis of the age of onset shows significant differences of means corresponding to the expectations of the hypothetic diagnostic components. Regarding duration of cycles, significant differences of means between the groups are not to be found.