Investigations on the acute effects of neuropeptides on the pituitary-adrenocortical function in normal and cold-stressed rats. I. Bombesin and neuromedin B.

@article{Malendowicz1995InvestigationsOT,
  title={Investigations on the acute effects of neuropeptides on the pituitary-adrenocortical function in normal and cold-stressed rats. I. Bombesin and neuromedin B.},
  author={Ludwik K. Malendowicz and Gastone Giovanni Nussdorfer},
  journal={Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie},
  year={1995},
  volume={47 1},
  pages={
          31-4
        }
}
  • L. Malendowicz, G. Nussdorfer
  • Published 1995
  • Medicine, Biology
  • Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
The effects of a subcutaneous bolus injection of 2 micrograms bombesin (BM) or neuromedin B (NMB) on the function of the hypothalamo-pituitary-adrenocortical (HPA) axis were investigated in both normal and cold-stressed rats. The blood concentrations of ACTH, corticosterone (B) and aldosterone (ALDO) were measured by specific radioimmunoassays 1, 2 or 4 h after the neuropeptide administration. Cold stress strikingly enhanced plasma levels of ACTH, B and ALDO, and these rises lasted unchanged… Expand
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