Investigations of the mechanism of the "proline effect" in tandem mass spectrometry experiments: the "pipecolic acid effect".

@article{Raulfs2014InvestigationsOT,
  title={Investigations of the mechanism of the "proline effect" in tandem mass spectrometry experiments: the "pipecolic acid effect".},
  author={Mary Disa M Raulfs and Linda A. Breci and Matthew C. Bernier and Omar M Hamdy and Ashley Janiga and Vicki H. Wysocki and John C Poutsma},
  journal={Journal of the American Society for Mass Spectrometry},
  year={2014},
  volume={25 10},
  pages={
          1705-15
        }
}
The fragmentation behavior of a set of model peptides containing proline, its four-membered ring analog azetidine-2-carboxylic acid (Aze), its six-membered ring analog pipecolic acid (Pip), an acyclic secondary amine residue N-methyl-alanine (NMeA), and the D stereoisomers of Pro and Pip has been determined using collision-induced dissociation in ESI-tandem mass spectrometers. Experimental results for AAXAA, AVXLG, AAAXA, AGXGA, and AXPAA peptides are presented, where X represents Pro, Aze, Pip… CONTINUE READING
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