Investigations of the attenuation induced in foot-and-mouth disease virus by a chemical mutagen

@article{Maes1972InvestigationsOT,
  title={Investigations of the attenuation induced in foot-and-mouth disease virus by a chemical mutagen},
  author={Roland F. Maes},
  journal={Archiv f{\"u}r die gesamte Virusforschung},
  year={1972},
  volume={37},
  pages={19-33}
}
Foot-and-mouth disease virus adapted to adult mice was cloned and compared to the same virus after its treatment with a mutagenin vitro. After treatment, a viral clone was isolated that was partially attenuated for adult mice. The two viral clones were indistinguishable in their inactivation rates with antiserum, urea and iodine, as well as in their susceptibility to urea and guanidine incorporated in the growth medium. Both clones were equally inhibited in their multiplication on primary… CONTINUE READING

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