Investigations of inter- and intraindividual relationships between exposure to oral salmon calcitonin and a surrogate marker of pharmacodynamic efficacy

@article{Karsdal2009InvestigationsOI,
  title={Investigations of inter- and intraindividual relationships between exposure to oral salmon calcitonin and a surrogate marker of pharmacodynamic efficacy},
  author={Morten Asser Karsdal and Inger Byrjalsen and Kim S. Henriksen and Bente Juul Riis and Claus Christiansen},
  journal={European Journal of Clinical Pharmacology},
  year={2009},
  volume={66},
  pages={29-37}
}
The aims of the study were to investigate interindividual variations in the bioavailability of salmon calcitonin (sCT) following single oral 0.8 mg doses at three different times of the day, and intraindividual variation in sCT bioavailability at each end of a 14-day treatment period. We also investigated correlations between exposure to sCT and levels of the bone resorption biomarker serum C-terminal telopeptide of collagen type I (CTX-I). Participants were from two randomized, double-blind… CONTINUE READING