Investigations of genotoxic activity of the antimicrobial/ antiviral agent FS-1 in rodents by means of the micronucleus and the comet assays

@article{Nersesyan2011InvestigationsOG,
  title={Investigations of genotoxic activity of the antimicrobial/ antiviral agent FS-1 in rodents by means of the micronucleus and the comet assays},
  author={Armen Nersesyan and Alexander Ivanovich Ilin and Marat Kulmanov and Rafael Muradyan and Gohar Parsadanyan and Gayane Zalinyan and Naira Chobanyan},
  journal={Archive of Oncology},
  year={2011},
  volume={19},
  pages={55-58}
}
6 SUMMARY Background: FS-1 is a complex of iodine and synthesized polysaccharides and it is very effective against a number of microbe and virus strains. The aim of the study was to evaluate possible genotoxic properties of FS-1. Methods: The compound was studied in rat and mouse bone marrow micronucleus (MN) assay and the comet assay in murine peripheral blood leukocytes, hepatocytes, and kidney cells. Two treatment protocols were applied, namely acute and subacute ones. In the first protocol… 
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Genotoxic activity of the new pharmaceutical FS-1 in Salmonella/microsome test and mouse lymphoma L5178Y cells.
TLDR
The drug is not genotoxic, which is advantageous because many antibacterial/antiviral drugs possess such activity, and in both test-systems in all experiments completely negative results were obtained.
New Antituberculosis Drug FS-1

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