Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease.

@article{Weisberg2003InvestigationsOA,
  title={Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease.},
  author={Ilan S Weisberg and Eric Park and Karla V. Ballman and Peter P Berger and M Brad Nunn and Daniel S Suh and Andrew P Breksa and Timothy A. Garrow and Rima Rozen},
  journal={Atherosclerosis},
  year={2003},
  volume={167 2},
  pages={205-14}
}
Hyperhomocysteinemia, a risk factor for cardiovascular disease, can be caused by genetic mutations in enzymes of homocysteine metabolism. Homocysteine remethylation to methionine is catalyzed by folate-dependent methionine synthase, or by betaine-homocysteine methyltransferase (BHMT), which utilizes betaine as the methyl donor. Since genetic variants in folate-dependent remethylation have been reported to increase risk for cardiovascular disease and other common disorders, we screened BHMT for… CONTINUE READING
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