Investigations into the structure and composition of beta-cyclodextrin/poly(acrylic acid) microspheres.

@article{Bibby1999InvestigationsIT,
  title={Investigations into the structure and composition of beta-cyclodextrin/poly(acrylic acid) microspheres.},
  author={David C. Bibby and N. Michael Davies and Ian G Tucker},
  journal={International journal of pharmaceutics},
  year={1999},
  volume={180 2},
  pages={161-8}
}
Microspheres composed of the hydrophilic polymer poly(acrylic acid) (PAA), with and without beta-cyclodextrin (beta-CD), were prepared by a water-in-oil (w/o) solvent evaporation technique. Microspheres were characterised for particle size, beta-CD and residual oil content. The type of matrix formed during microsphere synthesis was investigated by solid state carbon 13C NMR, in vitro release of beta-CD and swelling measurements. A high encapsulation efficiency of the beta-CD was observed (?90… CONTINUE READING