Investigations into the regulation of histone H2B monoubiquitination

  title={Investigations into the regulation of histone H2B monoubiquitination},
  author={Andrei Shchebet},
Transcription-associated chromatin modifications are recognized now as important regulators of gene expression. One of them, the monoubiquitination of lysine 120 of histone H2B (H2Bub1), is associated with actively transcribed genes. It was shown to change the physical properties of the chromatin as well as serve as a recognition mark for regulatory chromatin-binding proteins. The misregulation of H2Bub1-modifying machinery has been observed to be tightly linked with different types of cancer… CONTINUE READING

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