Investigations into the regulation and function of the SH2 domain-containing protein-tyrosine phosphatase, SHP-1

@article{Tsui2006InvestigationsIT,
  title={Investigations into the regulation and function of the SH2 domain-containing protein-tyrosine phosphatase, SHP-1},
  author={Florence W.L. Tsui and Alberto Mart{\'i}n and John Wang and Hing Wo Tsui},
  journal={Immunologic Research},
  year={2006},
  volume={35},
  pages={127-136}
}
Our laboratory is interested in identifying genes relevant to diseases. Our approach is to use spontaneous mouse mutants with immunological defects and decipher the molecular basis of the phenotypes. In the early 1990s, our attention was focused on the motheaten and viable motheaten mouse mutants. We used these mutant mice as a model system for elucidating the genetic and cellular events contributing to expression of normal hematopoietic and immune function. Our initial goal was to identify the… CONTINUE READING

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