Investigations into the polymorphic properties of N,N-dimethyltryptamine by X-ray diffraction and differential scanning calorimetry

  title={Investigations into the polymorphic properties of N,N-dimethyltryptamine by X-ray diffraction and differential scanning calorimetry},
  author={Alain Gaujac and James L. Ford and Nicola M. Dempster and Jailson Bittencourt de Andrade and Simon D. Brandt},
  journal={Microchemical Journal},
Abstract The powerful psychoactive features of N , N -dimethyltryptamine (DMT) have sparked the imagination of many research disciplines for several decades. One of the key chemical features associated with compound identity is the determination of melting points. The descriptions of both melting points and morphology associated with DMT free base have long been a source of interest and discussion, especially when considering that these values encountered in the scientific literature range… Expand
4 Citations
Synthesis and characterization of high-purity N,N-dimethyltryptamine (DMT) hemifumarate for human clinical trials.
The synthesized and characterized DMT hemifumarate, a high-purity water-soluble DMT that met regulatory standards for administration to humans with major depressive disorder, and was minimally 99.9% pure. Expand
Theoretical Aspects of Differential Scanning Calorimetry as a Tool for the Studies of Equilibrium Thermodynamics in Pharmaceutical Solid Phase Transitions
It was demonstrated that the heat quantity obtained from the DSC thermogram was related to the thermodynamic enthalpy of the phase transition (ΔHP) via: ΔH = Δ HP/(1 + K− 1) where K was the equilibrium constant. Expand
Phase Transition Enthalpy Measurements of Organic and Organometallic Compounds and Ionic Liquids. Sublimation, Vaporization, and Fusion Enthalpies from 1880 to 2015. Part 2. C11–C192
The second part of this compendium concludes with a collection of phase change enthalpies of organic molecules inclusive of C11–C192 reported over the period 1880–2015. Also included are phase changeExpand
Synthesis of polyfunctional triethoxysilanes by ‘click silylation’
Abstract The copper-catalyzed ‘click silylation’ has been exploited for the chemical modification of γ-azidopropyltriethoxysilane (AzPTES) with a wide range of terminal alkynes (1a–1v) in a one-potExpand


Characterization of the synthesis of N,N-dimethyltryptamine by reductive amination using gas chromatography ion trap mass spectrometry.
An impurity profile of a synthetic route to the hallucinogenic N,N-dimethyltryptamine (DMT) is established and holds great promise in the area of forensic chemistry where development of reliable analytical methods for the detection, identification, and quantification of DMT are crucial and also in pharmaceutical analysis where DMT might be prepared for use in human clinical studies. Expand
Application of analytical methods for the structural characterization and purity assessment of N,N-dimethyltryptamine, a potent psychedelic agent isolated from Mimosa tenuiflora inner barks
Abstract N , N -dimethyltryptamine (DMT) is a psychoactive indole alkaloid present in beverages consumed in religious ceremonies and in neo-shamanic rituals all around the world. It is a substanceExpand
Fingerprint analysis of thermolytic decarboxylation of tryptophan to tryptamine catalyzed by natural oils.
The analytical characterization of this preparation procedure was carried out using gas chromatography-ion trap single and tandem stage mass spectrometry in electron and chemical ionization mode that led to the identification of previously unreported 1-mono and 1,1-disubstituted tetrahydro-beta-carboline (THBCs) by-products. Expand
Polymorph Selection with Morphology Control Using Solvents
Sulfathiazole is a highly polymorphic model system exhibiting at least five polymorphic forms:  I, II, III, IV, and V. Polymorph stability is known to be susceptible to solvent environment, and it isExpand
Characterisation of a proposed internet synthesis of N,N-dimethyltryptamine using liquid chromatography/electrospray ionisation tandem mass spectrometry.
This study demonstrated the impact on product purity of doubtful synthetic methodologies discussed on the internet by characterisation of the second step of the Breath of Hope Synthesis, which was based on the methylation of tryptamine. Expand
Analytical methods for psychoactive N,N-dialkylated tryptamines
Abstract Many N , N -dialkylated tryptamine derivatives can induce altered states of consciousness in humans. The term “hallucinogen” is often used when describing the effect on the human mind, andExpand
Characterization of temperature-induced phase transitions in five polymorphic forms of sulfathiazole by terahertz pulsed spectroscopy and differential scanning calorimetry.
Terahertz pulsed spectroscopy proves to be a rapid and complementary alternative to other physical characterization techniques reported in the literature for distinguishing between the five polymorphic forms of the drug sulfathiazole. Expand
Thermal analysis and calorimetric methods in the characterisation of polymorphs and solvates
Abstract The definitions and thermodynamic background for interpreting thermal analysis data are presented in this review. Most drug substances and excipients which have been reported to displayExpand
The use of high-speed differential scanning calorimetry (Hyper-DSC™) to study the thermal properties of carbamazepine polymorphs
Abstract The thermal properties of two polymorphs of the drug carbamazepine, Forms I and III, were studied using high-speed differential scanning calorimetry (DSC). Previously, accurate determinationExpand
qNMR: An applicable method for the determination of dimethyltryptamine in ayahuasca, a psychoactive plant preparation
Abstract Ayahuasca is an Amazonian plant beverage obtained by infusing the pounded stems of Banisteriopsis caapi in combination with the leaves of Psychotria viridis. P. viridis contains theExpand