Investigations into the pharmacological effects of spongiatriol.

  title={Investigations into the pharmacological effects of spongiatriol.},
  author={J. F. Marwood},
  journal={The Australian journal of experimental biology and medical science},
  volume={60 3},
  • J. F. Marwood
  • Published 1982 in
    The Australian journal of experimental biology…
Acute intraperitoneal doses of spongiatriol, a compound extracted from marine sponges, caused blood pressure but not heart rate to fall in conscious hypertensive rats in a dose-dependent manner up to 50 mg/kg at which dose mean blood pressure fell 24%. Diarrhoea also resulted. Chronic oral doses (50 mg/kg every 3 h) lowered blood pressure by 73 mmHg after… CONTINUE READING