Investigations into the decomposition of aminoacyl-substituted monosaccharide scaffolds from a drug discovery library.


This study investigated the unexpected decomposition and associated intermediates of compound 1, a specific member of a drug discovery library based on a monosaccharide scaffold. LC/MS and NMR spectroscopic analyses indicated that, under acidic conditions, 1 can be converted into the 4-aminogalactoside 2, due to cleavage of the 4-aminobutanoyl side chain… (More)
DOI: 10.1039/c5ob00122f


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