Investigational treatment options in microscopic colitis

  title={Investigational treatment options in microscopic colitis},
  author={Ahmed Madisch and Andrea Morgner and Manfred Stolte and Stephan Miehlke},
  journal={Expert Opinion on Investigational Drugs},
  pages={1829 - 1837}
Collagenous and lymphocytic colitis are the two recognized major presentations of microscopic colitis. Both diseases present with chronic watery diarrhea and a chronic inflammatory infiltrate in the colonic mucosa without specific endoscopic abnormalities, and hence diagnosis is established by histology. Recent epidemiological studies suggest that microscopic colitis may affect as many patients as Crohn's disease or ulcerative colitis. The cause of these diseases is unknown; however, several… 
1 Citations
Microscopic Colitis: Epidemiology, Pathophysiology, Diagnosis and Current Management—An Update 2013
  • M. Storr
  • Medicine
    ISRN gastroenterology
  • 2013
The present knowledge of the epidemiology, the pathophysiology, and the diagnosis of microscopic colitis is summarized and the former and the present treatment options are discussed.


Collagenous colitis and microscopic colitis: the watery diarrhea-colitis syndrome.
Nine patients with chronic watery diarrhea and nonspecific colonic mucosal inflammation followed for 1-5 yr are presented, and histological variability of collagenization and inflammation during the course of collagenous colitis and microscopic Colitis and the clinical feature of watery diarrhoea suggest that these two entities be grouped together as theWatery diarrhea-colitis syndrome.
Microscopic Colitis: An Update
Empirical data demonstrates that microscopic colitis is a more common cause of diarrhea than previously shown, and studies on treatment have demonstrated budesonide to be most effective, although other treatments also hold promise.
Collagenous colitis. A clinical, histological, and ultrastructural study.
The morphological changes in colorectal biopsy specimens are diagnostic, showing an excessive intercryptal subepithelial collagen deposition throughout the large bowel.
Collagenous colitis: histopathology and clinical course.
Although variable in clinical presentation, treatment-free remissions are common in collagenous colitis, and initial histology, except possibly for Paneth cell metaplasia, did not reliably predict severity or course of disease.
Collagenous, microscopic and lymphocytic colitis. An evolving concept
The aim of this review is to present an overview of collagenous Colitis and lymphocytic colitis and to propose an unifying concept with an adapted terminology.
Incomplete remission with short-term prednisolone treatment in collagenous colitis: a randomized study.
Prednisolone 50 mg daily for 2 weeks induces incomplete remission in patients with chronic diarrhoea due to collagenous colitis, and effect was defined as > 50% reduction of either stool frequency or weight.
Collagenous Colitis and Yersinia enterocolitica Infection
It is proposed that Yersiniaenterocolitica infection may be a triggering factor for the development of collagenous colitis in some cases.
Budesonide in the Treatment of Collagenous Colitis
Budesonide seems to be of therapeutic benefit in collagenous colitis, and prospective randomized long-term studies are needed to support this hypothesis.
The prevalence, anatomic distribution, and diagnosis of colonic causes of chronic diarrhea.