Investigational topical anticholinergics in clinical development for the treatment of hyperhidrosis

@article{Gregoriou2021InvestigationalTA,
  title={Investigational topical anticholinergics in clinical development for the treatment of hyperhidrosis},
  author={Stamatios Gregoriou and Anna Campanati and Dimitrios Rigopoulos and Alexandros Stratigos and George Kontochristoulos},
  journal={Expert Opinion on Investigational Drugs},
  year={2021},
  volume={30},
  pages={479 - 482}
}
Focal hyperhidrosis has an incidence of up to 4.8%. % [1]. Abnormal sympathetic hyperactivity is the best documented component of its pathogenesis.Management of focal hyperhidrosis includes aluminu... 
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3 Citations

3 Citations

Sofpironium bromide: an investigational agent for the treatment of axillary hyperhidrosis
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An overview of pharmaceutical characteristics, efficacy and safety data from phase II and III clinical trials on sofpironium bromide (SB), a topical anticholinergic agent that has been employed for the treatment of PAH and has already received its first approval in Japan in the form of 5% gel formulation.
The pharmacological treatment and management of hyperhidrosis
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The authors report on, in this narrative review, the emerging data from the literature focusing on the pharmacological treatments to draw up a drug treatment flow chart for patients with idiopathic hyperhidrosis, taking into consideration specific differences among axillary, palmoplantar, and craniofacialhyperhidrosis.
Synthetic Approaches to the New Drugs Approved During 2020.
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This Review is part of a continuing series presenting the most likely process-scale synthetic approaches to 44 new chemical entities approved for the first time anywhere in the world during 2020.

References

SHOWING 1-10 OF 21 REFERENCES
Oxybutynin 3% gel for the treatment of primary focal hyperhidrosis in adolescents and young adults
TLDR
Evaluated the efficacy and tolerability of oxybutynin 3% gel in adolescents and young adults with primary focal hyperhidrosis and found it to be safe and effective.
Topical glycopyrrolate reduces axillary hyperhidrosis
  • D. Baker
  • Medicine
    Journal of the European Academy of Dermatology and Venereology : JEADV
  • 2016
TLDR
The initial effectiveness of 1% and 2% topical glycopyrrolate spray is determined and this is compared with Botulinum toxin type A injections for the management of axillary hyperhidrosis.
Topical Treatment of Primary Focal Hyperhidrosis, Part 2.
  • E. Zur
  • Medicine
    International journal of pharmaceutical compounding
  • 2019
TLDR
This represents part 2 of a 2-part article on the topic of primary focal hyperhidrosis that provides a comprehensive review of the active pharmaceutical ingredients glycopyrronium salts and oxybutynin chloride in the treatment ofPrimary focalhyperhidrosis.
Efficacy and safety of topical glycopyrrolate in patients with facial hyperhidrosis: a randomized, multicentre, double‐blinded, placebo‐controlled, split‐face study
  • M. Y. Hyun, I. Son, C. Hong
  • Medicine, Psychology
    Journal of the European Academy of Dermatology and Venereology : JEADV
  • 2015
Although facial hyperhidrosis has been frequently associated with a diminished quality of life, various conservative modalities for its management are still far from satisfactory.
A glycopyrronium bromide 1% cream for topical treatment of primary axillary hyperhidrosis: efficacy and safety results from a phase IIIa randomized controlled trial
TLDR
1% GPB cream may provide an effective new treatment option exhibiting a good safety profile for patients with primary axillary hyperhidrosis.
A phase 2a randomized controlled study to evaluate the pharmacokinetic, safety, tolerability and clinical effect of topically applied Umeclidinium in subjects with primary axillary hyperhidrosis
TLDR
Umeclidinium (UMEC) is a long‐acting muscarinic antagonist (LAMA) developed as a dermal formulation that can be used as a treatment for hyperhidrosis.
Management Strategies Of Palmar Hyperhidrosis: Challenges And Solutions
TLDR
This review will provide an update on current and emerging concepts of management for excessive hand sweating to help clinicians optimize therapeutic decision-making.
Efficacy and Safety of Topical Sofpironium Bromide Gel for the Treatment of Axillary Hyperhidrosis: A Phase II, Randomized, Controlled, Double-Blinded Trial.
Safety and efficacy of topical formulations containing 0·5, 1 and 2% glycopyrronium bromide in patients with primary axillary hyperhidrosis: a randomized, double‐blind, placebo‐controlled study
TLDR
The objective of this study was to assess safety and tolerability, efficacy and pharmacokinetics, of escalating concentrations of glycopyrronium bromide (GPB), a competitive antagonist of muscarinic acetylcholine receptor mAChR, in subjects with axillary hyperhidrosis.
Topical Oxybutynin 10% Gel for the Treatment of Primary Focal Hyperhidrosis: A Randomized Double-blind Placebo-controlled Split Area Study.
TLDR
Twice-daily topical application of oxybutynin 10% gel appears to be an effective, safe and well-tolerated treatment for focal primary hyperhidrosis.
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