Investigational new insulin glargine 300 U/ml has the same metabolism as insulin glargine 100 U/ml

@inproceedings{Steinstraesser2014InvestigationalNI,
  title={Investigational new insulin glargine 300 U/ml has the same metabolism as insulin glargine 100 U/ml},
  author={Axel Steinstraesser and Ronald V. Schmidt and Karin Bergmann and Raphael Dahmen and Reinhard Becker},
  booktitle={Diabetes, obesity & metabolism},
  year={2014}
}
Insulin glargine is processed in vivo into soluble 21(A) -Gly-human insulin (M1), the principal moiety responsible for metabolic effects, and subsequently into M2. This sub-study compared metabolism and metabolite pharmacokinetic (PK) profiles of investigational new insulin glargine U300 (Gla-300) with insulin glargine 100 U/ml (Gla-100, Lantus®, Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, Germany) in people with type 1 diabetes. Participants received 0.4 (n = 18) or 0.6 U/kg Gla-300 (n… CONTINUE READING
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