Investigational drugs in thrombotic thrombocytopenic purpura.

  title={Investigational drugs in thrombotic thrombocytopenic purpura.},
  author={Patrizia Noris and Carlo Luigi Balduini},
  journal={Expert opinion on investigational drugs},
  volume={20 8},
INTRODUCTION Familial and acquired, idiopathic, thrombotic thrombocytopenic purpura (TTP) are life-threatening thrombotic microangiopathies characterized by thrombocytopenia and microangiopathic hemolytic anemia deriving from a deficiency of a disintegrin-like and metalloprotease with thrombospondin repeats (ADAMTS)13 activity induced by genetic defects or autoantibodies. Although the introduction of plasma exchange in 1991 made these conditions curable, many patients still die from TTP and… CONTINUE READING


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Effect of intravenous Noris & Balduini Expert Opin

  • SA Jensen, K Dalhoff
  • 2011

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