Investigation on tolerance development to subchronic blockade of mGluR5 in models of learning, anxiety, and levodopa-induced dyskinesia in rats

@article{Gravius2008InvestigationOT,
  title={Investigation on tolerance development to subchronic blockade of mGluR5 in models of learning, anxiety, and levodopa-induced dyskinesia in rats},
  author={Andreas Gravius and Andrzej Dekundy and Jens Nagel and Lorenzo Mor{\`e} and Małgorzata Pietraszek and Wojciech Danysz},
  journal={Journal of Neural Transmission},
  year={2008},
  volume={115},
  pages={1609-1619}
}
In the present study, we evaluated the effects of subchronic blockade of mGluR5 by 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) on learning, anxiety and levodopa-induced dyskinesia in rats. In addition, we excluded the possibility that subchronic treatment produced pharmacokinetic changes using brain microdialysis. MTEP (5 mg/kg) impaired spatial learning in a radial maze task and contextual fear conditioning (CFC) when administered acutely, and the same effect was observed following a… CONTINUE READING