Investigation on the absorption of phillyrin and forsythiaside in rat digestive tract

@article{Li2011InvestigationOT,
  title={Investigation on the absorption of phillyrin and forsythiaside in rat digestive tract},
  author={Yun-Xia Li and Cheng Peng and Liang-hong Ye and Ruo-qi Zhang and Xue-hua Jiang},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={2011},
  volume={36},
  pages={79-85}
}
In the present study, an in situ rat model was employed to systemically investigate the absorption of phillyrin and forsythiaisde. Three concentrations of phillyrin (0.2, 0.4 and 1.5 mg) were tested and the results showed that phillyrin cannot be absorbed in the digestive tract. The absorption rates of forsythiaside in stomach were 7.773, 7.228 and 6.751% h−1 for 0.5, 1 and 2.5 mg, and no significant difference was found in different concentrations. The absorptions of forsythiaside in intestine… CONTINUE READING