Investigation on the ZBG-functionality of phenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase inhibitors.

@article{Musso2015InvestigationOT,
  title={Investigation on the ZBG-functionality of phenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase inhibitors.},
  author={Loana Musso and Raffaella Cincinelli and Valentina Zuco and Franco Zunino and Alessandra Nurisso and Muriel Cuendet and Giuseppe Giannini and Loredana Vesci and Claudio Pisano and Sabrina Dallavalle},
  journal={Bioorganic & medicinal chemistry letters},
  year={2015},
  volume={25 20},
  pages={4457-60}
}
A series of alternative Zn-binding groups were explored in the design of phenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors. Most of the synthesized compounds were less effective than the parent hydroxamic acid. However, the profile of activity shown by the analog bearing a hydroxyurea head group, makes this derivative… CONTINUE READING