Investigation on possible antioxidative properties of the NMDA-receptor antagonists ketamine, memantine, and amantadine in comparison to nicanartine in vitro.

@article{Lupp1998InvestigationOP,
  title={Investigation on possible antioxidative properties of the NMDA-receptor antagonists ketamine, memantine, and amantadine in comparison to nicanartine in vitro.},
  author={Amelie Lupp and Steffen Kerst and Elke Karge and G{\"u}nter Quack and Wolfgang Klinger},
  journal={Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie},
  year={1998},
  volume={50 4-6},
  pages={
          501-6
        }
}
  • A. Lupp, S. Kerst, +2 authors W. Klinger
  • Published 1 September 1998
  • Chemistry, Medicine
  • Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
Possible antioxidative properties of three N-methyl-D-aspartate (NMDA)-receptor antagonists, the anesthetic ketamine and the antiparkinson drugs memantine and amantadine were investigated in vitro on the microsomal cytochrome P450 (P450) system of rat livers and on rat whole blood chemiluminescence in comparison to nicanartine, a substance with known antiatherosclerotic, hypolipemic and antioxidative capacity. For this purpose, the effects on NADPH- and iron-stimulated lipid peroxidation (LPO… Expand
Evaluation of possible pro- or antioxidative properties and of the interaction capacity with the microsomal cytochrome P450 system of different NMDA-receptor ligands and of taurine in vitro.
  • A. Lupp, S. Kerst, E. Karge
  • Chemistry, Medicine
  • Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
  • 2003
TLDR
Only the non-competitive NMDA-receptor antagonists seem to have antioxidative properties and interactions with the P450 system and thus with the biotransformation of other substances are to be expected. Expand
Protective role of pentobarbital pretreatment for NMDA-R activated lipid peroxidation is derived from the synergistic effect on endogenous anti-oxidant in the hippocampus of rats
TLDR
It is suggested that PBT anesthesia not only suppresses NMDA-R activated free radical generation but also synergistically enhances the increased basal endogenous anti-oxidant ability in the hippocampus. Expand
Ketamine and Midazolam Differentially Inhibit Nonadrenergic Noncholinergic Lower Esophageal Sphincter Relaxation in Rabbits: Role of Superoxide Anion and Nitric Oxide Synthase
TLDR
It is suggested that ketamine inhibits NANC LES relaxation by the extracellular production of superoxide anion, and that midazolam inhibits it by the inhibition of nitric oxide synthase activity. Expand
Inhibitory effects of memantine on human cytochrome P450 activities: prediction of in vivo drug interactions
TLDR
Memantine represents a new, potent, selective inhibitor of recombinant CYP2B6, which may prove useful for screening purposes during early phases of in vitro drug metabolism studies with new chemical entities. Expand
Changes in Antioxidant Sytem, Lipid Peroxidation, Heart and Respiratory Rate and Rectal Temperature with Ketamine and Ketamine-Xylazine Anaestesia in Tuj Rams
The objective of this study was to determine if a ketamine or ketamine-xylazine had any effect on the antioxidant defence system and on lipid peroxidation as thiobarbituric acid substance (TBARS) inExpand
Changes in antioxidant system, lipid peroxidation, heart and respiratory rate and rectal temperature with ketamine and ketamine-xylazine anaesthesia in Tuj rams.
The objective of this study was to determine if a ketamine or ketamine-xylazine had any effect on the antioxidant defence system and on lipid peroxidation as thiobarbituric acid substance (TBARS) inExpand
Regulation of cytochrome P450 gene expression by ketamine: a review
TLDR
The effects of ketamine on the regulation of CYP gene expression are discussed, exploring aspects of cytoskeletal remodeling, mitochondrial functions, and calcium homeostasis. Expand
A Comparative Free Radical Scavenging Evaluation of Amantadine and Rasagiline
TLDR
This study proved the intrinsic activity of rasagiline and amantadine which may be beneficial in attenuating the oxidative stress pathways, which were considered responsible for many degenerative diseases. Expand
Effect of ischemia on TBARS and lactate production in several cerebral regions of anaesthetised and awake rats.
TLDR
Data showed the particular vulnerability of striatum to ischemia and the possible opposite effects of an anaesthesia and a potential link between lipid peroxidation and acidosis. Expand
The effects of NMDA receptor antagonists over intestinal ischemia/reperfusion injury in rats.
TLDR
Ketamine's protective effects over ischemia/reperfusion do not appear to be NMDA mediated, but they could be playing a role in protecting the intestine against is chemia-induced functional changes. Expand
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