Investigation on positive correlation of increased brain iron deposition with cognitive impairment in Alzheimer disease by using quantitative MR R2′ mapping

@article{2011InvestigationOP,
  title={Investigation on positive correlation of increased brain iron deposition with cognitive impairment in Alzheimer disease by using quantitative MR R2′ mapping},
  author={Yuan-yuan Qin 覃媛媛 and Wen-zhen Zhu 朱文珍 and Chuanjia Zhan 占传家 and Ling-yun Zhao 赵凌云 and Jian-zhi Wang 王建枝 and 青 QingTian田 and 伟 WeiWang王},
  journal={Journal of Huazhong University of Science and Technology [Medical Sciences]},
  year={2011},
  volume={31},
  pages={578-585}
}
Brain iron deposition has been proposed to play an important role in the pathophysiology of Alzheimer disease (AD). The aim of this study was to investigate the correlation of brain iron accumulation with the severity of cognitive impairment in patients with AD by using quantitative MR relaxation rate R2′ measurements. Fifteen patients with AD, 15 age- and sex-matched healthy controls, and 30 healthy volunteers underwent 1.5T MR multi-echo T2 mapping and T2* mapping for the measurement of… Expand

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