Investigation of various factors affecting encapsulation on the In-Cap automatic capsule-filling machine

  title={Investigation of various factors affecting encapsulation on the In-Cap automatic capsule-filling machine},
  author={Renuka R Nair and Murti Vemuri and Praful Agrawala and Soo-il Kim},
  journal={AAPS PharmSciTech},
The purpose of this study was to determine the factors that influence fill weight and weight variability of capsules produced on the In-Cap and to assess any differences in terms of capsule defects between gelatin and HPMC (Quali-V) shells. The In-Cap is an automatic tamping type capsule-filling machine and the low output of ≈3000 capsules/hour makes it ideal for early formulation development and phase I/IIa clinical supplies manufacture. Four commonly used excipients (Avicel PH101, Avicel… 

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  • B. E. Jones
  • Materials Science
    International journal of pharmaceutics
  • 2001
Encapsulation of clomacran phosphate [2-chloro-9[3-(dimethylamino) propyl]acridan phosphate] I. Effect of flowability of powder blends, lot-to-lot variability, and concentration of active ingredient on weight variation of capsules filled on an automatic capsule-filling machine.
Abstract A correlation has been shown to exist between the flow properties of clomacran phosphate powder blends and capsule fill weight variation when an automatic capsule-filling machine is used.A