Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics.

Abstract

Serotonergic transmission is considered relevant in the pathophysiology and the treatment of schizophrenia. Tryptophan hydroxylase (TPH) is the rate limiting enzyme in the biosynthesis of serotonin. While the TPH1 gene has been found to be associated with schizophrenia, studies focusing on TPH2 variants did not yield conclusive results for schizophrenia or… (More)
DOI: 10.1016/j.jpsychires.2012.04.021

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Cite this paper

@article{Schuhmacher2012InvestigationOT, title={Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics.}, author={Anna Schuhmacher and Tim Becker and Dan Rujescu and Boris B. Quednow and Leonhard Lennertz and Michael Wagner and Jens Benninghoff and Marcella Rietschel and Heinz Haefner and Petra Franke and Wolfgang W{\"o}lwer and Wolfgang Gaebel and Wolfgang Maier and Rainald Moessner}, journal={Journal of psychiatric research}, year={2012}, volume={46 8}, pages={1073-80} }