Investigation of toxic metabolites during drug development.

  title={Investigation of toxic metabolites during drug development.},
  author={Kevin B Park and Dominic P Williams and Dean J Naisbitt and Neil R. Kitteringham and Munir Pirmohamed},
  journal={Toxicology and applied pharmacology},
  volume={207 2 Suppl},
Adverse drug reactions (ADRs) are a significant human health problem. Any organ system can be affected, including the liver, skin and kidney. Drug-induced liver injury is the most frequent reason for the withdrawal of an approved drug from the market, and it also accounts for up to 50% of cases of acute liver failure. The clinical picture is often diverse, even for the same drug. Mild, asymptomatic effects occur at a relatively high frequency with a number of drugs. Idiosyncratic toxicity is… CONTINUE READING